from the early 2010s, the USA was struck with the “opioid crisis”, as illicit fentanyl and new artificial opioids (NSOs) flooded the unlawful drug industry. Benzimidazole opioids are µ-opioid receptor (MOR) agonists with antinociceptive Qualities. Although the potency of Some compounds is similar to that of morphine, the pharmacological activi